We study computational and experimental RNA biology.

RNA regulation linking genetics and disease

The epitranscriptome and its regulation

Recent Publications


Fu, Ting; Amoah, Kofi; Chan, Tracey W.; Bahn, Jae Hoon; Lee, Jae-Hyung; Terrazas, Sari; Chong, Rockie; Kosuri, Sriram; Xiao, Xinshu

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes Journal Article

In: Nature Communications, vol. 15, no. 3335, 2024.

Links | BibTeX

Huang, Elaine; Frydman, Clara; Xiao, Xinshu

Navigating the landscape of epitranscriptomics and host immunity Journal Article

In: Genome Res, vol. 34, no. 4, pp. 515–529, 2024, ISSN: 1549-5469.

Abstract | Links | BibTeX

Zheng, Rong; Dunlap, Mikayla; Bobkov, Georg O M; Gonzalez-Figueroa, Carlos; Patel, Khushali J; Lyu, Jingyi; Harvey, Samuel E; Chan, Tracey W; Quinones-Valdez, Giovanni; Choudhury, Mudra; Roux, Charlotte A Le; Bartels, Mason D; Vuong, Amy; Flynn, Ryan A; Chang, Howard Y; Nostrand, Eric L Van; Xiao, Xinshu; Cheng, Chonghui

hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing Journal Article

In: Mol Cell, 2024, ISSN: 1097-4164.

Abstract | Links | BibTeX

Quinones-Valdez, Giovanni; Amoah, Kofi; Xiao, Xinshu

Long-read RNA-seq demarcatescis- andtrans-directed alternative RNA splicing Unpublished

bioRxiv, 2024.

Abstract | Links | BibTeX

Hervoso, Jonatan L; Amoah, Kofi; Dodson, Jack; Choudhury, Mudra; Bhattacharya, Arjun; Quinones-Valdez, Giovanni; Pasaniuc, Bogdan; Xiao, Xinshu

Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia Journal Article

In: Am J Hum Genet, 2024, ISSN: 1537-6605.

Abstract | Links | BibTeX

Recent News

July 3, 2024

We welcome Taylor Harris and Jingyu Xu to our lab!

June 25, 2024

Our paper “Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia” is published at AJHG.  A great collaboration with the Pasaniuc lab! Congratulations to Jonatan and coauthors!!

June 21, 2024

Our paper “Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing” is now on BioRxiv!  Check out the new tool isoLASER on our Github.  Congratulations to Gio and Kofi!

June 17, 2024

Alison and Ryan graduate from UCLA CaSB!  Congratulations!!!

June 14, 2024

We welcome Armen and Weijian to join our lab officially!