We study computational and experimental RNA biology.

RNA regulation linking genetics and disease

The epitranscriptome and its regulation

Recent Publications

2025

Seo, Hyomin; Cuddleston, Winston H.; Fu, Ting; Navarro, Elisa; Parks, Madison; Allan, Amanda; Efthymiou, Anastasia G.; Breen, Michael S.; Xiao, Xinshu; Raj, Towfique; Humphrey, Jack

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells Journal Article

In: BioRxiv, 2025.

Links | BibTeX

Siqueira, Mirian Krystel De; Nouhi, Zaynab; Zhao, Yutian; Wang, Siqi; Xiao, Xinshu; Yang, Xia; Hulea, Laura; Villanueva, Claudio J

Protocol to perform polysome profiling in primary differentiating murine adipocytes Journal Article

In: STAR Protoc, vol. 6, no. 2, pp. 103799, 2025, ISSN: 2666-1667.

Abstract | Links | BibTeX

Wang, Jing; Deng, Xiaoqian; Jian, Tianshen; Yin, Shanshan; Chen, Linzhi; Vergnes, Laurent; Li, Zhehao; Liu, Huoyuan; Lee, Ryan; Lim, Sin Yee; Bahn, Jae Hoon; Xiao, Xinshu; Zhu, Xianmin; Hu, Ganlu; Reue, Karen; Liu, Yizhi; Fan, Guoping

DNA methyltransferase 1 modulates mitochondrial function through bridging mC RNA methylation Journal Article

In: Mol Cell, 2025, ISSN: 1097-4164.

Abstract | Links | BibTeX

2024

Fu, Ting; Amoah, Kofi; Chan, Tracey W.; Bahn, Jae Hoon; Lee, Jae-Hyung; Terrazas, Sari; Chong, Rockie; Kosuri, Sriram; Xiao, Xinshu

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes Journal Article

In: Nature Communications, vol. 15, no. 3335, 2024.

Links | BibTeX

Huang, Elaine; Frydman, Clara; Xiao, Xinshu

Navigating the landscape of epitranscriptomics and host immunity Journal Article

In: Genome Res, vol. 34, no. 4, pp. 515–529, 2024, ISSN: 1549-5469.

Abstract | Links | BibTeX

Recent News

April 30, 2025

Check out this STAR Protocol “Protocol to perform polysome profiling in primary differentiating murine adipocytes” with Dr. Claudio J Villanueva’s lab.

April 30, 2025

We are glad to have contributed to this collaborative project with Dr. Guoping Fan’s lab: “DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation“, published at Molecular Cell.

April 1, 2025

We welcome Richard to rotate in our lab!

March 21, 2025

Carlos and Elaine presented their projects beautifully at the GRC RNA editing conference!

March 17, 2025

Our collaborative paper is online at BioRixv: Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.  Congratulations to Ting and all authors!