We study computational and experimental RNA biology.

RNA regulation linking genetics and disease

The epitranscriptome and its regulation

Recent Publications

2024

Fu, Ting; Amoah, Kofi; Chan, Tracey W.; Bahn, Jae Hoon; Lee, Jae-Hyung; Terrazas, Sari; Chong, Rockie; Kosuri, Sriram; Xiao, Xinshu

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes Journal Article

In: Nature Communications, vol. 15, no. 3335, 2024.

Links | BibTeX

Huang, Elaine; Frydman, Clara; Xiao, Xinshu

Navigating the landscape of epitranscriptomics and host immunity Journal Article

In: Genome Res, vol. 34, no. 4, pp. 515–529, 2024, ISSN: 1549-5469.

Abstract | Links | BibTeX

Zheng, Rong; Dunlap, Mikayla; Bobkov, Georg O M; Gonzalez-Figueroa, Carlos; Patel, Khushali J; Lyu, Jingyi; Harvey, Samuel E; Chan, Tracey W; Quinones-Valdez, Giovanni; Choudhury, Mudra; Roux, Charlotte A Le; Bartels, Mason D; Vuong, Amy; Flynn, Ryan A; Chang, Howard Y; Nostrand, Eric L Van; Xiao, Xinshu; Cheng, Chonghui

hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing Journal Article

In: Mol Cell, 2024, ISSN: 1097-4164.

Abstract | Links | BibTeX

2023

Chan, Tracey W; Dodson, Jack P; Arbet, Jaron; Boutros, Paul C; Xiao, Xinshu

Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis Journal Article

In: Cancer Res, vol. 83, no. 3, pp. 374–385, 2023, ISSN: 1538-7445.

Abstract | Links | BibTeX

R, Zheng; M, Dunlap; J, Lyu; C, Gonzalez-Figueroa; G, Bobkov; SE, Harvey; TW, Chan; G, Quinones-Valdez; M, Choudhury; A, Vuong; RA, Flynn; HY, Chang; X, Xiao; C, Cheng

LINE-associated cryptic splicing induces dsRNA-mediated interferon response and tumor immunity Online

2023, visited: 24.02.2023.

Links | BibTeX

Recent News

June 14, 2024

We welcome Armen and Weijian to join our lab officially!

June 4, 2024

Our collaboration paper on “hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing” is published at Molecular Cell. A great collaboration with Dr. Chonghui Cheng’s lab at Baylor College of Medicine.  Congratulations to all authors!

May 22, 2024

We welcome undergraduate student Angela Zhang to our lab!

May 15, 2024

Our review on “Navigating the landscape of epitranscriptomics and host immunity” is published at Genome Research.  Congratulations Elaine and Clara.

April 18, 2024

UCLA News reports about our recent MPRA paper.  Read here.