We study computational and experimental RNA biology.

RNA regulation linking genetics and disease

The epitranscriptome and its regulation

Recent Publications

2025

Seo, Hyomin; Cuddleston, Winston H.; Fu, Ting; Navarro, Elisa; Parks, Madison; Allan, Amanda; Efthymiou, Anastasia G.; Breen, Michael S.; Xiao, Xinshu; Raj, Towfique; Humphrey, Jack

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells Journal Article

In: BioRxiv, 2025.

Links | BibTeX

Siqueira, Mirian Krystel De; Nouhi, Zaynab; Zhao, Yutian; Wang, Siqi; Xiao, Xinshu; Yang, Xia; Hulea, Laura; Villanueva, Claudio J

Protocol to perform polysome profiling in primary differentiating murine adipocytes Journal Article

In: STAR Protoc, vol. 6, no. 2, pp. 103799, 2025, ISSN: 2666-1667.

Abstract | Links | BibTeX

Wang, Jing; Deng, Xiaoqian; Jian, Tianshen; Yin, Shanshan; Chen, Linzhi; Vergnes, Laurent; Li, Zhehao; Liu, Huoyuan; Lee, Ryan; Lim, Sin Yee; Bahn, Jae Hoon; Xiao, Xinshu; Zhu, Xianmin; Hu, Ganlu; Reue, Karen; Liu, Yizhi; Fan, Guoping

DNA methyltransferase 1 modulates mitochondrial function through bridging mC RNA methylation Journal Article

In: Mol Cell, 2025, ISSN: 1097-4164.

Abstract | Links | BibTeX

Khan, Arshad H; Bagley, Jared R; LaPierre, Nathan; Gonzalez-Figueroa, Carlos; Spencer, Tadeo C; Choudhury, Mudra; Xiao, Xinshu; Eskin, Eleazar; Jentsch, James D; Smith, Desmond J

Differing Genetics of Saline and Cocaine Self-Administration in the Hybrid Mouse Diversity Panel Journal Article

In: Genes Brain Behav, vol. 24, no. 3, pp. e70029, 2025, ISSN: 1601-183X.

Abstract | Links | BibTeX

Huang, Elaine; Fu, Ting; Zhang, Ling; Yan, Guanao; Yamamoto, Ryo; Terrazas, Sari; Nguyen, Thuy Linh; Gonzalez-Figueroa, Carlos; Khanbabaei, Armen; Bahn, Jae Hoon; Varada, Rajagopal; Amoah, Kofi; Hervoso, Jonatan; Paulsen, Michelle T; Magnuson, Brian; Ljungman, Mats; Li, Jingyi Jessica; Xiao, Xinshu

Genetic variants affecting RNA stability influence complex traits and disease risk Journal Article

In: Nat Genet, 2025, ISSN: 1546-1718.

Abstract | Links | BibTeX

Recent News

October 4, 2025

We are glad to have contributed to this paper: Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease. A great collaboration with Winston, Jack, Towfique and others on the team!

September 16, 2025

Alison, Anna, Ryan and Siqi present their work at the QCB retreat!

September 6, 2025

Check out the UCLA Newsroom feature on our study: “How fast mRNA degrades linked to autoimmune disease risk“! Huge thanks to Holly Ober for writing such a clear and engaging piece!

September 6, 2025

Our paper “Genetic variants affecting RNA stability influence complex traits and disease risk” is published in Nature Genetics. Congratulations to our outstanding first author, Elaine Huang, for leading this challenging and impactful study, and all coauthors for their critical contributions. This work was made possible through fantastic collaborations with Jessica Li’s lab and Mats Ljungman’s lab.

September 4, 2025

We are grateful for a Catalyst Award from UCLA’s BSCRC!