We study computational and experimental RNA biology.

RNA regulation linking genetics and disease

The epitranscriptome and its regulation

Recent Publications

2025

Seo, Hyomin; Cuddleston, Winston H.; Fu, Ting; Navarro, Elisa; Parks, Madison; Allan, Amanda; Efthymiou, Anastasia G.; Breen, Michael S.; Xiao, Xinshu; Raj, Towfique; Humphrey, Jack

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells Journal Article

In: BioRxiv, 2025.

Links | BibTeX

Siqueira, Mirian Krystel De; Nouhi, Zaynab; Zhao, Yutian; Wang, Siqi; Xiao, Xinshu; Yang, Xia; Hulea, Laura; Villanueva, Claudio J

Protocol to perform polysome profiling in primary differentiating murine adipocytes Journal Article

In: STAR Protoc, vol. 6, no. 2, pp. 103799, 2025, ISSN: 2666-1667.

Abstract | Links | BibTeX

Wang, Jing; Deng, Xiaoqian; Jian, Tianshen; Yin, Shanshan; Chen, Linzhi; Vergnes, Laurent; Li, Zhehao; Liu, Huoyuan; Lee, Ryan; Lim, Sin Yee; Bahn, Jae Hoon; Xiao, Xinshu; Zhu, Xianmin; Hu, Ganlu; Reue, Karen; Liu, Yizhi; Fan, Guoping

DNA methyltransferase 1 modulates mitochondrial function through bridging mC RNA methylation Journal Article

In: Mol Cell, 2025, ISSN: 1097-4164.

Abstract | Links | BibTeX

Khan, Arshad H; Bagley, Jared R; LaPierre, Nathan; Gonzalez-Figueroa, Carlos; Spencer, Tadeo C; Choudhury, Mudra; Xiao, Xinshu; Eskin, Eleazar; Jentsch, James D; Smith, Desmond J

Differing Genetics of Saline and Cocaine Self-Administration in the Hybrid Mouse Diversity Panel Journal Article

In: Genes Brain Behav, vol. 24, no. 3, pp. e70029, 2025, ISSN: 1601-183X.

Abstract | Links | BibTeX

2024

Fu, Ting; Amoah, Kofi; Chan, Tracey W.; Bahn, Jae Hoon; Lee, Jae-Hyung; Terrazas, Sari; Chong, Rockie; Kosuri, Sriram; Xiao, Xinshu

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes Journal Article

In: Nature Communications, vol. 15, no. 3335, 2024.

Links | BibTeX

Recent News

June 17, 2025

We are glad to have contributed to this collaborative project with Dr. Desmond Smith’s lab: “Differing Genetics of Saline and Cocaine Self-Administration in the Hybrid Mouse Diversity Panel“, published at Genes, Brain and Behavior.

June 1, 2025

We welcome Richard to officially join our lab!

May 20, 2025

Congratulations to Anna for receiving the GATP training grant!

April 30, 2025

Check out this STAR Protocol “Protocol to perform polysome profiling in primary differentiating murine adipocytes” with Dr. Claudio J Villanueva’s lab.

April 30, 2025

We are glad to have contributed to this collaborative project with Dr. Guoping Fan’s lab: “DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation“, published at Molecular Cell.